Carole Lombard was offered the lead role in a proposed melodrama, "Smiler with a Knife," to be directed by a newcomer at RKO named Orson Welles. She turned it down, opting to return to screwball comedy in Mr. & Mrs. Smith (1941). Welles refused to make "Smiler" without her. After briefly considering Lucille Ball for the lead role, he began work on Citizen Kane (1941).
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Saoirse Ronan landed the role of Susie Salmon based on an audition tape she sent in. They were so impressed by the tape, that no meetings or further auditions were necessary before offering her the lead role in this movie.
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