There were indeed fears about the Glass Harmonica (invented by Benjamin Franklin), but claims that the instrument was deadly were unfounded as players won't get lead poisoning from touching lead glass. However, its unworldly quality is true, for the sounds produced are of a frequency which the human ear finds hard to locate.
Mr. Holmes ending explained (spoilers)
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With Roger recovering from a serious reaction to several wasp stings, Mr. Holmes bequeaths his farmhouse and bees to his housekeeper and son, upon his death. The final scene shows Mr. Holmes setting up a Zen meditation rock circle on the top of the hill overlooking the sea. In the middle of the rock circle, Mr. Holmes is seen beginning meditation and prayers.
Mr. Holmes ending explained (spoilers)
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